Whip Whitaker (Denzel Washington) wakes before it’s time to take off on a new flight, after an evening of drinking and sex with one of his plane’s stewardesses, Katerina Marquez (Nadine Velazquez). Still trying to rouse himself from his hangover, his phone rings, and he answers a call from his ex-wife Deana (Garcelle Beauvais). Deana wants to discuss putting their son through a private school, but Whip doesn’t want to discuss it at the moment, claiming he’ll talk to her about it when he gets back to Atlanta.
While Katerina quickly heads off to the airport to prepare, Whip is unable to collect himself until he snorts a line of cocaine. This wakes him up, and he is next headed to the airport, where rain pounds the building and the airplanes. Whip does a quick inspection of the airplane, then enters into the airplane, speaking with a flight attendant named Margaret (Tamara Tunie), and meeting his co-pilot Ken Evans (Brian Geraghty).
Ken seems a little apprehensive of Whip (who is wearing sunglasses), but goes along with his story that he’s alright to fly. The plane takes off through rain, and Whip pushes it higher and faster, attempting to find a break in the clouds, causing the ride to seem downright turbulent. However, once Whip finds a break in the storm, the plane stabilizes, and the passengers applaud.
Shortly after this, Whip addresses the passengers personally, while secretly pouring some mini-vodka bottles into a bottle of orange juice. After disposing of the bottles, Whip returns to the cockpit, and naps while Ken takes over.
Whip awakens in an Atlanta hospital with minor injuries. He is greeted by his old friend Charlie Anderson (Bruce Greenwood), who now represents the airline’s pilots union. He tells Whip his heroism saved 96 of 102 people on board. An NTSB official informs him Katerina was among those killed, and that Evans has been put into a coma.
When he meets Charlie and attorney Hugh Lang (Don Cheadle), they explain that the NTSB performed a toxicology screen while he was unconscious in the hospital that revealed he was intoxicated, which could result in Whip going to prison on both drug and manslaughter charges. Lang promises to get the toxicology report ruled inadmissible on technical grounds, but Whip leaves in a fury and takes refuge in his father